Preimplantation genetic diagnosis (PGT) at FertiMedica

Preimplantation genetic diagnosis (PGT) is an advanced diagnostic tool that allows the detection of genetic defects in embryos before they are transferred to the uterine cavity during transfer.

Types of PGT:

  1. PGT-A (PGS) (preimplantation genetic diagnosis of aneuploidy)

Detects abnormal number of chromosomes in embryos.

  1. PGT-M (PGD) (preimplantation monogenic genetic diagnosis)

Detects specific mutations within a single gene

  1. PGT-SR (PGS) (preimplantation genetic diagnosis of structural chromosome reorganization)

Detects structural changes in chromosomes

Indications for performing PGT diagnostics:

PGT is recommended for couples who are at high risk of genetic defects in their offspring. Indications for preimplantation diagnosis are recurrent miscarriages and women over 35 years of age. The use of PGT can increase the chances of implantation and development of a healthy pregnancy, because embryos without genetic defects are selected for transfer.

Why is it worth using PGT diagnostics?

Preimplantation genetic diagnosis gives couples the opportunity to avoid passing on inherited genetic defects to their offspring. Increases the effectiveness of IVF procedures by selecting genetically correct embryos. PGT can increase the chances of a healthy pregnancy and reduce the risk of miscarriage and complications related to genetic defects in the embryos.

Safety of using PGT diagnostics

Preimplantation genetic diagnosis is a procedure that involves some risk, but is considered safe for the embryo. Here are some important facts about PGT safety:

  1. Immediate risk to the embryo: The PGT procedure involves the collection of several trophoectoderm cells from the blastocyst stage embryo. The risk of stopping the further development of the embryo is minimal. After collecting the material for testing, the blastocyst is subjected to the vitrification process and stored until the results are obtained and the transfer date is set.
  2. Diagnostic techniques: PGT uses advanced diagnostic techniques of DNA analysis – Next Generation Sequencing (NGS). Constant development and improvement of analysis techniques increase their effectiveness and precision. Embryologists and geneticists try to minimize any risk to the embryo by using appropriate protocols and procedures.
  3. Potential for diagnostic errors: despite the advancement of PGT techniques, there is a small risk of diagnostic errors. This is due to several factors, such as the number of cells analyzed or the presence of mosaicism (mixed genetic lineage). It is important to consult a specialist after receiving the result.

Please note that at FertiMedica we approach each case individually. The decision to carry out PGT should be made after consulting a doctor who, with the help of the embryological team, will be able to present specific risks and benefits of performing PGT.

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